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Determinants of Bone Mineral Density in Adult Women

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KMID : 0892720000040020189
µµÁØÇü ( Doh Joon-Hyung ) - ¿µ³²´ëÇб³ ÀÇ°ú´ëÇÐ ¿¹¹æÀÇÇб³½Ç

°­º¹¼ö ( Kang Pock-Soo ) - ¿µ³²´ëÇб³ ÀÇ°ú´ëÇÐ ¿¹¹æÀÇÇб³½Ç
ÁÖ ¸® ( Joo Ree ) - ¿µ³²´ëÇб³ ÀÇ°ú´ëÇÐ ¿¹¹æÀÇÇб³½Ç
±è¼®¹ü ( Kim Suk-Bum ) - ¿µ³²´ëÇб³ ÀÇ°ú´ëÇÐ ¿¹¹æÀÇÇб³½Ç
±è»ó±Ô ( Kim Sang-Kyu ) - ¿µ³²´ëÇб³ ÀÇ°ú´ëÇÐ ¿¹¹æÀÇÇб³½Ç

Abstract

1997³â 1¿ùºÎÅÍ 10¿ù±îÁö ¿µ³²´ëÇб³ ÀÇ°ú´ëÇÐ ºÎ¼Óº´¿ø¿¡¼­ Á¾ÇÕ°ËÁøÀ» ¹ÞÀº 40¼¼ ÀÌ»ó ¿©¼º Áß ÀüÈ­¼³¹®Á¶»ç¿¡ ÀÀÇÑ 347¸íÀ» ´ë»óÀ¸·Î ¿¬·É¿¡ ´ëÇÑ Â¦Áþ±â¸¦ ½Ç½ÃÇÏ¿© 153¸í¿¡ ´ëÇÏ¿© Á¶»ç ºÐ¼®ÇÏ¿´´Ù. °¢Á¾ ÀßȯÀÇ °ú°Å·Â, »êºÎÀΰúÀû º´·Â, ¿îµ¿ ¹× ½Ä»ýÈ°½À°ü µîÀ» ¼³¹«Á¶»çÇÏ¿´°í, Á¾ÇÕ°ËÁø°á°úÁß º» ¿¬±¸¿¡ ÇÊ¿äÇÑ »ýÈ­ÇÐÀû °Ë»çÄ¡¿Í °ñ¹Ðµµ°Ë»çÄ¡¸¦ Á¶»çºÐ¼®ÇÏ¿´´Ù. ¼öÁýµÈ ÀÚ·á´Â T score¿¡ µû¶ó Á¤»ó±º, °ñ°¨¼ÒÁõ±º, °ø´Ù°øÁõ±ºÀÇ ¼¼ ±ºÀ¸·Î ºÐ·ùÇÏ¿© one-way ANOVA, ±³Â÷ºÐ¼®À» ÅëÇØ ºñ±³ÇÏ¿´À¸¸ç, °ñ¹Ðµµ¿Í °ü·Ã¼ºÀÌ ÀÖ´Â º¯¼öµéÀÇ »ó°ü°ü°è¸¦ ºÐ¼®ÇÏ¿© ´ÙÁßȸ±ÍºÐ¼®À» ÅëÇØ È¸±Í¹æÁ¤½ÄÀ» ±¸ÇÏ¿´´Ù. °ñ¹Ðµµ °Ë»ç°á°ú T scoreÀÇ ÀüüÆò±ÕÀº -1.6À̾úÀ¸¸ç Á¤»ó±ºÀÌ -0.09, °ñ°¨¼Ò±ºÀÌ -1.78, ±×¸®°í °ñ´Ù°øÁõ±ºÀÌ -2.97À̾ú´Ù. °ñ´Ù°øÁõ±ºÀÇ Æò±Õ½ÅÀå°ú üÁßÀÌ °¡Àå ³·¾ÒÀ¸¸ç »ýÈ­ÇÐÀû °Ë»çÁß LDH°¡ °ñ´Ù°øÁõ±ºÀÌ °¡Àå ³·¾Ò´Ù. °ñ°¨¼ÒÁõ±º¿¡¼­ Æó°æ±â°£ÀÌ 153.0°³¿ù·Î °¡Àå ±æ¾úÀ¸¸ç °ñ´Ù°øÁõ±º ¹× Á¤»ó±º ¼øÀ̾ú´Ù. °ñ¹Ðµµ¿Í À¯ÀÇÇÑ »ó°ü°è¼ö¸¦ °¡Áö´Â °ÍÀ¸·Î´Â ½ÅÀå(0.217), üÁß(0.246), ALP(-0.255), Ãâ»êȽ¼ö(-0.169) ¹× Æó°æ±â°£(-0.261) µîÀ̾úÀ¸¸ç, T score¸¦ Á¾¼Óº¯¼ö·Î ÇÑ ´ÙÁßȸ±Í ºÐ¼®°á°ú Æó°æ±â°£, üÁß, ¹× ALP°¡ °ñ¹Ðµµ¿¡ À¯ÀÇÇÑ ¿µÇâÀ» ¹ÌÄ¡´Â º¯¼ö¿´´Ù. Æó°æ±â°£ÀÌ ±ä °í·ÉÀÇ Å°°¡ ÀÛ°í üÁßÀÌ ÀûÀº ¿©¼ºÀϼö·Ï °ñ´Ù°ñÁõÀÇ À§Ç輺ÀÌ ³ôÀº °ÍÀ¸·Î ³ªÅ¸³µÀ¸¸ç, À̵鿡 ´ëÇÑ ¿¹¹æÀû 1Â÷ º¸°Ç±³À°(primary education)À» ½Ç½ÃÇÔÀ¸·Î½á °ñÀý µîÀÇ ³ëÀΰǰ­¹®Á¦¸¦ °¨¼Ò½ÃÅ°´Â µ¥ µµ¿òÀ» ÁÙ ¼ö ÀÖÀ» °ÍÀÌ´Ù. ¶ÇÇÑ °ñ¹Ðµµ ÃøÁ¤ ¿Ü¿¡ ALP °°Àº »ýÈ­ÇÐÀû ÃøÁ¤Ä¡¸¦ °ñ´Ù°øÁõÀÇ ÁöÇ¥·Î¼­ ÀÌ¿ëÇÒ ¼ö ÀÖÀ» °ÍÀÌ´Ù.

This study was conducted to predict the determinants of bone mineral density (BMD). The data were obtained from the female aged above 40 who got health examination and check BMD in department of medical screening center, Yeungnam University Hospital from January to October, 1997. Among these people, we performed inquiry by telephone to 347 subjects through random sampling and the study was conducted. The inquiry included questions about family history of osteoporosis, obstetric history including age at menarche, menopause, parity, breast feeding, past use of oral contraceptives, and tubal ligation, and life style factors such as the amount of physical activity, consumption of milk and coffee, smoking and alcohol drinking. Biomedical parameters affecting the BMD such as Alkaline phosphatase (ALP) , serum calcium and anthropometric data predicting BMD were also checked. BMD was measured by dual energy x-ray absorptiometry by means of a Norland XR-26 at lumbar spine(L2-L4) for each subject. The BMD data were presented as T scores.

Using multiple stepwise regression, we found that age, weight, and ALP were independent predictors of vertebral mineral density. All the variables accounted for 48.78% of the total variance of vertebral bone mass.
KeyWords

bone mineral density, adult woman, osteoporosis
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